HYALOFAST®: A Hyaluronic Acid-Based Matrix Supports Regeneration of Hyaline-like Cartilage

Hyalofast is One-Step Cartilage Repair made from a 3D non-woven scaffold composed of HYAFF®, a benzyl ester of hyaluronic acid (HA). In combination with mesenchymal stem cells (MSCs), Hyalofast supports the regeneration of hyaline-like cartilage.

Unique handling properties

  • Hyalofast can be easily and quickly implanted via arthroscopy or mini-arthrotomy
  • The soft texture allows it to conform easily to any lesion shape
  • It readily adheres to the site of application without requiring additional fixation in most cases
  • The scaffold can be applied in any orientation or stacked due to its uniform single-layer 3D structure
  • Two available sizes allow large lesions to be easily covered: 2×2 cm and 5×5 cm

Hyalofast goes the distance

Clinical evidence shows Hyalofast plus MSCs to be an effective and safe treatment with excellent outcomes in different joints1-10, and stable up to long-term follow-up12.

The Hyalofast Advantage


  • Acts as a scaffold for bone marrow aspirate or as a chondroprotective coverage after bone marrow stimulation procedures. Hyalofast can be used with or without fibrin sealant.


  • No fixation is required in most cases. It is easily adaptable to any lesion shape.


  • Excellent clinical and MRI results in the treatment of osteochondral defects of ankle and knee.1-6 Hyaline-like cartilage confirmed by MRI T2 mapping.1,2,5


Hyalofast is CE-marked as a biodegradable support for the entrapment of mesenchymal stem cells for the repair of chondral and osteochondral lesions. It acts as a support for bone marrow aspirate or as a chondroprotective coverage which favors in situ residence of mesenchymal stem cells after their mobilization following bone marrow stimulation procedures.

For complete product information, please refer to product IFU or the Hyalofast website.

Anika products may not be available in all geographies. Product availability is subject to the regulatory clearances in individual markets. Please reach out to your local representative or Contact Us if you have questions about specific market approvals. Hyalofast is not approved for use in the United States.

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  1. Battaglia M., et al. Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle. Eur J Radiol. 2011 Nov;80(2):e132-9. Epub 2010.
  2. Vannini F., et al. One step treatment of juvenile osteochondritis dissecans in the knee: Clinical results and T2 mapping characterization. Orthop Clin North Am. 2012; 43(2):237-44.
  3. Buda R., et al. One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results. Musculoskelet Surg. 2013 August; 97 (2): 145–151. Epub 2013 Feb 19 .
  4. Gobbi A., et al. Matrix-Induced Autologous Chondrocyte Implantation versus Multipotent Stem Cells for the treatment of large patellofemoral chondral lesions: a non-randomized prospective trial. Cartilage. Cartilage 2015, Vol. 6 (2) 82– 97.
  5. Buda R., et al. Regenerative treatment in osteochondral lesions of the talus: autologous chondrocyte implantation versus one-step bone marrow derived cells transplantation. Int Orthop. 2015 May;39(5):893-900
  6. Gobbi A., et al. One step surgery with multipotent stem cells and Hyaluronan based scaffold for the treatment of full thickness chondral defects of the knee in patients older than 45 years. Knee Surg Sports Traumatol Arthrosc 2017 Aug; 25 (8): 2494-2501.Epub 2016 Jan 14
  7. Data on file.
  8. Gobbi A., et al. One-Stage Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Activated Bone Marrow-Derived Mesenchymal Stem Cells Compared With Microfracture: Five-Year Follow-up. Am J Sports Med. 2016 Nov;44(11):2846-2854. Epub 2016 Jul 29.
  9. Tahta M., et al. Arthroscopic treatment of osteochondral lesions of the talus: nanofracture vs Hyaluronic acid-based cell-free scaffold with concentration of autologous bone marrow aspirate. J Orthop Surg (Hong Kong) 2017 May-Aug; 25 (2): 1-5.
  10. Sofu A., et al. Results of Hyaluronic Acid Based Cell-Free Scaffold Application in combination With Microfracture for the Treatment of Osteochondral Lesions of the Knee: 2-Year Comparative Study. Arthroscopy. 2017 Jan; 33 (1): 209-216.
  11. Rafols C. et al. Severe Chondral Injuries Associated to FAI Treated with Hyalofast Scaffold, Microfractures and Peripheral Blood Stem Cells. Clinical and Imaging Results with a Minimum Follow-Up of 12 Months. J Hip Preserv Surg. 2016; 3 (Suppl 1)
  12. Gobbi A. et al. Long-term Clinical Outcomes of One-Stage Cartilage Repair in the Knee with Hyaluronic Acid–Based Scaffold Embedded with Mesenchymal Stem Cells Sourced From Bone Marrow Aspirate Concentrate. Am J Sports Med. 2019 Jun;47(7):1621-1628